Healthcare is a defensive sector -- people need medicine regardless of the economy. Biotech is a high-risk sub-sector where FDA trial results can move stocks 50%+ in a day. The GLP-1 obesity drug wave (Ozempic, Zepbound) is the sector's biggest current theme.
Large pharma (JNJ, PFE, MRK): diversified drug portfolios, stable dividends.
Biotech (MRNA, REGN, AMGN): fewer products, massive upside/downside on trials.
Health insurers (UNH, CVS): benefit from aging population and ACA.
Medical devices (MDT, SYK, ISRG): recurring procedure revenue.
Specialty pharma (LLY, ABBV): focused on high-margin blockbuster drugs.
The FDA approval calendar is more important than earnings for biotech stocks.
PDUFA date: FDA deadline to approve/reject a drug application.
Phase 3 trial results: the largest catalyst for clinical-stage biotechs.
Stock reaction: approval = +30-100%; rejection = -50-80%.
Never hold through an FDA decision without understanding the risk.
Related: ETFs for New Traders • Gap Up & Gap Down • Position Sizing